Iran's consulate in the Syrian capital Damascus was flattened on Monday in what Syrian and Iranian media described as an Israeli air strike.
A Lebanese security source, speaking to Reuters, said one of the dead was Mohammad Reza Zahedi, a senior commander in Iran's Revolutionary Guards Corps (IRGC). Iranian state television said several Iranian diplomats had been killed.
Israel, which has repeatedly hit Iranian targets during the six-month war in Gaza, declined to comment on the incident, following its usual practice.
An Israeli military spokesperson said: "We do not comment on reports in the foreign media."
Iran's Tasnim news agency said five people were killed in the Israeli strike. Syria's SANA state news agency reported an unspecified number of deaths and injuries.
Since the Palestinian group Hamas' attack on Israel on October 7, Israel has ramped up airstrikes in Syria against Lebanon's Hezbollah militia and Iran's Guards, both of which support the government of President Bashar Al Assad.
The head of the National Counterterrorism Center resigned on Tuesday, becoming the first and most senior member of US President Donald Trump's administration to resign over the war in Iran, saying Tehran posed no imminent threat to the United States.
Israel claimed on Tuesday to have killed Iran's security chief, while a senior Iranian official said the new supreme leader had rejected de-escalation offers conveyed by intermediaries.
An Israeli airstrike killed at least three people in the Gaza Strip on Tuesday, local health authorities said, the latest violence jeopardising the ceasefire which has been under strain during the Israeli-US war against Iran.
A UN inquiry has started investigating a fatal strike on a primary school on the first day of US-Israeli attacks on Iran, one of its members told reporters on Tuesday.
Civilians are paying a heavy price as the war in Lebanon continues to expand, driving death, injuries and displacement the United Nations said on Tuesday.
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