Northern Ireland defender Jonny Evans will be sidelined for the "next few weeks" due to a thigh strain he suffered in the first half of United's 4-3 Champions League defeat at FC Copenhagen.
Manchester United said late on Friday.
He joins a lengthy injury list at United, who remain without defenders Lisandro Martinez, Luke Shaw, Tyrell Malacia and midfielder Casemiro.
The 35-year-old will miss Northern Ireland's final Euro 2024 qualifiers against Finland and Denmark. Northern Ireland, who sit fifth in Group H with six points, travel to Finland next Friday before hosting Denmark on November 20.
Evans rejoined United on a one-year deal in September, eight years after leaving Old Trafford and has started five league games.
United lie in eighth place in the top-flight after picking up 18 points in 11 matches and host promoted Luton Town later on Saturday.
Middle East’s largest creator-led golf event returns to Dubai
Australia on front foot in fifth Ashes test
Chelsea confirm Rosenior as new head coach
Sabalenka eases through Brisbane opener, Kyrgios falls at first hurdle
Australian Open prize fund reaches record $75 million
