Liverpool suffered their first defeat in the Premier League this season, going down 3-0 at Watford.
All the goals came in the second-half with Ismaila Sarr scoring a double and Troy Deeney netting his side's third.
Jurgen Klopp's men missed the chance of setting a top-flight record of 19 straight victories and were five games away from equalling Arsenal's all-time best unbeaten run of 49 matches.
The win helped Watford move out of the relegation places.
West Ham also climbed out of the bottom three with a 3-1 win over Southampton, while Bournemouth are now in the drop zone after their 2-2 draw at home to Chelsea.
Elsewhere, Newcastle finished 0-0 with Burnley and Brighton lost 1-0 at home to Crystal Palace.
In Sunday's games, Tottenham host Wolves and Manchester United head to Everton.
F1's Bahrain and Saudi races set to be cancelled amid ongoing regional tensions
Georgia caught in doping scandal as players allegedly swapped urine samples
F1 leader Russell puts Mercedes on pole for China sprint race
Everton's Moyes defends 'brilliant' Arsenal amid criticism of their playing style
Alcaraz sets up Medvedev Indian Wells semi-final, Sabalenka advances
